There were a few different possibilities with what this comic might be. It is about the adventures of the last man on earth after all the other men have been mysteriously killed simultaneously. It could be an interesting intellectual exercise, which would mean that it deserves its reputation. It could be a manifestation of all of men's fears and insecurities about women and sex, in which case it could be potentially entertaining if it worked, or it could be an uneasy combination of the two.
Unfortunately, it is the latter. Mr. Vaughan seems to me to be pretty screwed up about women, but because he has pretensions to seriousness, the whole thing falls very flat. He lost me half way through when everyone started behaving in ways that were unbelievable, but the presentation was pretty earnest with the campy elements not handled well. Won't be continuing with this.